Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection
نویسندگان
چکیده
منابع مشابه
Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection
The latent reservoir is a major barrier to HIV eradication. Reservoir size is emerging as an important biomarker to assess the likelihood of HIV remission in the absence of antiretroviral therapy (ART) and may be reduced by earlier initiation of ART that restricts HIV spread into CD4+ T cells. Reservoir size is traditionally measured with a quantitative viral outgrowth assay (QVOA) that induces...
متن کاملAntiretroviral Therapy in Early HIV Infection.
Antiretroviral therapy (ART) has transformed the course of human immunodeficiency virus (HIV) infection. More than two dozen HIV drugs are now available in resource-rich environments, and newer combination regimens have ever-increasing efficacy and decreasing toxicity. As a result, life expectancy and quality of life are close to normal for HIV-infected persons with access to these medications....
متن کاملPrevention of HIV-1 infection with early antiretroviral therapy.
BACKGROUND Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. METHODS In nine countries, we enrolled 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-negative; 54% of the subjects were from Africa, and 50% of infected partners were men. HIV-1-infected subjects ...
متن کاملAntiretroviral Therapy in Early HIV Infection
Antiretroviral therapy (ART) has transformed the course of human immunodeficiency virus (HIV) infection. More than two dozen HIV drugs are now available in resource-rich environments, and newer combination regimens have ever-increasing efficacy and decreasing toxicity. As a result, life expectancy and quality of life are close to normal for HIV-infected persons with access to these medications....
متن کاملFive-year follow-up of children with perinatal HIV-1 infection receiving early highly active antiretroviral therapy
BACKGROUND Early highly active antiretroviral therapy (HAART), started within the first months of age, has been proven to be the optimal strategy to prevent immunological and clinical deterioration in perinatally HIV-infected children. Nevertheless, data about long-term follow-up of early treated children are lacking. METHODS We report data from 40 perinatally HIV-infected-children receiving ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0170548